Research

A single-cell computational analysis of nitric oxide–related gene programs in endothelial cells to investigate drug-specific mechanisms of endothelial dysfunction in human atherosclerosis.

A computational biology research project focused on endothelial dysfunction

Phase 1: Computational Analysis of Nitric Oxide–Associated Gene Signatures Reveals Differential Associations of Statins, ACEIs, and CCBs with Endothelial Dysfunction in Human Atherosclerotic Cells

Phase 1 establishes a novel nitric oxide Coupling Index and demonstrates its biological relevance by associating drug-responsive gene programs (statins, ACEIs, CCBs) with endothelial dysfunction at single-cell resolution.

Phase 1 and 2 Mechanistic Refinement and Project Extension: A single-cell computational analysis of nitric oxide–related gene programs in endothelial cells to investigate drug-specific mechanisms of endothelial dysfunction in human atherosclerosis

Phase 2 refines drug-responsive gene programs, incorporates endothelial subpopulation–specific analyses, and quantitatively tests the robustness and mechanistic specificity of drug–NO coupling relationships.

Research Projects